Can a vaccine protect fetuses and newborns from listeriosis

Listeriosis is a fatal infection for fetuses and newborns with two clinical main morbidities in the neonatal period, meningitis and diffused cutaneous lesions.

amy.pregnant.listeriaIn this study, we vaccinated pregnant females with two gold glyconanoparticles (GNP) loaded with two peptides, listeriolysin peptide 91–99 (LLO91–99) or glyceraldehyde-3-phosphate dehydrogenase 1–22 peptide (GAPDH1–22). Neonates born to vaccinated mothers were free of bacteria and healthy, while non-vaccinated mice presented clear brain affections and cutaneous diminishment of melanocytes.

Therefore, these nanoparticle vaccines are effective measures to offer pregnant mothers at high risk of listeriosis interesting therapies that cross the placenta.

Pregnancy vaccination with gold glyco-nanoparticles carrying Listeria monocytogenes peptides protects against Listeriosis and brain- and cutaneous-associated morbidities

Nanomaterials 2016, 6(8), 151; doi:10.3390/nano6080151 (registering DOI)

R Calderón-Gonzalez, H Terán-Navarro, E Frande-Cabanes, E Ferrández-Fernández, J Freire, S Penadés, S Yañez-Díaz, C Alvarez-Domínguez

http://www.mdpi.com/2079-4991/6/8/151